Clinical Trials

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8 clinical trials were found.


A Single-Blinded, Prospective Controlled Study to Evaluate the Role of Musculoskeletal Ultrasound as a Reliable Screening Modality in Predicting Initial Gout Flares in Asymptomatic Hyperuricemic Patients

The purpose of this research study is to find out if using ultrasound in patients with high blood levels of uric acid can predict if they are more likely to develop an acute gouty flare. An acute gouty flare is a medical condition that occurs when the body has trouble dealing with high levels of uric acid.  An acute gouty flare usually results in attacks of painful arthritis, especially in the smaller bones of the feet.  Ultrasound is a procedure that uses sound waves to take pictures of the inside of the body.

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Biomarkers of Rheumatic Diseases (02-159G)

The purpose of this research study, which is being conducted by the North American Rheumatoid Arthritis Consortium (NARAC), is to learn more about genetic factors that may contribute to RA. The cause of RA is not known, but research has indicated it is likely a combination of genetic and environmental factors. We collect blood for serum, plasma, DNA (the genetic material in your cells that you inherit from your parents), along with your health information in order to study cellular, biochemical and/or genetic function in people who have autoimmune diseases and their unaffected family. People with confirmed diagnosis of Rheumatoid Arthritis (RA) who have two biological living parents are invited to join the study. This research study does not involve any treatment and individual research results are not provided.

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Rheumatoid Arthritis - Lovastatin Therapy Study

This study will look at the effects of a drug called Lovastatin in the treatment of patients with mildly active rheumatoid arthritis (RA). Lovastatin is one of the “statin” drugs approved by the FDA for the treatment of high cholesterol, but it is currently not approved for treating RA. There is evidence from laboratory studies that Lovastatin may be beneficial in the treatment of mildly active RA. One purpose of this study is to determine if Lovastatin is effective in reducing the inflammation that is seen in patients with mildly active RA. Another purpose is to see if it is safe for treatment of mildly active RA. This study will look at the effects of Lovastatin by comparing subjects with RA who receive the study drug, Lovastatin, to those who do not.

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Rheumatology Specimen and Clinical Data Bank

The purpose of this research tissue bank is to collect, process and store samples until researchers need them to do research on rheumatologic diseases, such as systemic lupus erythematosus, rheumatoid arthritis, scleroderma and other autoimmune diseases.

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Role of Topical Tranexamic Acid in Total Hip Arthroplasty

Total hip replacement surgery is always associated with some blood loss. The purpose of this study is to see whether using tranexamic acid locally in the wound, in such procedures, will help reduce blood loss. Tranexamic acid is a drug which is known to affect the blood clotting system. It can help decrease blood loss. This drug has been commonly used to decrease blood loss in dental procedures, heart surgery procedures, and orthopedic procedures like hip and knee replacements. Tranexamic acid is a FDA approved drug. However, using tranexamic acid for total hip replacement is an off -label use which is not approved by the FDA. This study involves monitoring and recording blood loss by keeping a record of hemoglobin (protein that helps carry oxygen in the blood) levels. This study will also monitor the drug’s effects on recovery from surgery in the form of improvement in day to day functions after surgery.

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Systemic Biomarkers in Patients Undergoing Epidural Steroid Injection

The purpose of this research study is to learn more about causes for back pain and to help examine the effect of epidural steroid injections on proteins in the body that cause inflammation.  This study may help us develop new treatments to help ease back pain.

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The Influence of Operative Approach on Muscle Atrophy after Total Hip Arthroplasty - A Comparison of Anterior and Posterior Approaches

This research study is investigating the differences between varying surgical approaches on muscle damage and recovery after total hip replacement.  Total hip replacements can be performed through several different types of operative approaches.  Each of these different surgical approaches offers excellent success rates, and to date nobody has demonstrated that any specific approach is better than any other.

In this study, researchers are attempting to study the pattern of soft tissue damage that occurs with two different operative approaches.  Researchers are looking to see if there are any significant differences in the amount damage and recovery.  Researchers plan to study this with Magnetic Resonance Imaging (MRI) scans, which are considered a safe and non-invasive way of looking at the soft tissues around the hip.

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Mapping Autoimmune Phenotypes in Multiplex Families – MADGC 2 Study

The purpose of the MADGC 2 Study is to find the genes that make some families more likely than others to develop autoimmune diseases. We collect blood for serum, plasma, DNA (the genetic material in your cells that you inherit from your parents) and RNA, along with your health information in order to study cellular, biochemical and/or genetic function in people who have autoimmune diseases and their unaffected family members. As new technologies are developed, the MADGC 2 researchers will determine the kinds of research and analysis to be conducted, such as extensive DNA sequencing (determining the scientific information contained in the DNA), including sequencing the entire human genome (the entirety of a person’s hereditary information) of selected subjects. This research study does not involve any treatment and individual research results are not provided.

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